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KMID : 1145720220100020055
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Korean Herbal Medicine Informatics
2022 Volume.10 No. 2 p.55 ~ p.66
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Effects of aqueous extract of Pelodiscis Carapax on monosodium iodoacetate induced mice
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Chun Jin-Mi
Lee Ji-Hye
Nam Hyeon-Hwa
Moon Byeong-Cheol
Park Jun-Hong
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Abstract
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This study aimed to investigate the effects of aqueous extract of Pelodiscis Carapax (PCE) in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) mice. PCE (200 mg/kg) was orally administered to C57BL/6 mice for 2 weeks. After MIA injection (75 mg/mL), we performed a behavior test (open field test, rotarod test) followed by micro-computed tomography, histopathological analysis, and real-time quantitative PCR analysis on knee joint tissues. PCE treatment improved general gait locomotor activity, joint morphological features, and histopathological features compared to the MIA-induced mice. In addition, it confirmed that the mRNA expression levels of tissue inhibitor of metalloproteinases (TIMP)-1 in the joint tissues were increased in the PCE-treated group. Our result revealed that PCE treatment phenotypically improved OA symptoms.
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KEYWORD
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Pelodiscis Carapax, Monosodium iodoacetate, Osteoarthritis, Locomotor activity, Tissue inhibitor of metalloproteinases (TIMP)-1
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